The Hybrid Calibration Puzzle in Marvel’s Spider-Man 2 is a science puzzle that fans of the Marvel’s Spider-Man series should be used to by now. Peter comes across on his tour of the Emily-May Foundation when he is introduced to Dr. Foster. Dr. Foster is working on hybrid crops that can survive extreme conditions. This guide will show you how to tackle this puzzle and solve all three stages.
For more guides on Marvel’s Spider-Man 2, you should check out our guides on the Home Run Trophy, getting Hero Tokens fast, and solving Dr. Connor’s Kitchen Puzzle.
How to Solve the Hybrid Calibration Solution in Marvel’s Spider-Man 2
To solve the Hybrid Calibration puzzles in Marvel’s Spider-Man 2, you’ll need to put the hexes on tiles in the correct order. We’ll go through each puzzle with you.
In the first puzzle, you’ll need to make a hybrid plant. This is the tutorial puzzle that you should have no trouble with. Put all the tiles onto the board in any order. They’re all plants and will do what you need.

The second puzzle is where things get more difficult. Go ahead and slot the leaf at the top and connect it to a leaf hex in the middle. Next, just connect the blue water drop to the bottom left of the leaf and connect the sun hex to the right of the middle leaf.

The last puzzle seems like the most difficult because you need to actually meet certain criteria. It does not matter if you go over the attributes, you just need to make sure they’re all met. Put these hexes from left to right:
- Sun
- Water
- Leaf
- Water
- Leaf

Dr. Foster will tell you that you’ve done beautiful work and you will build great plants.
If you want to skip the puzzle at any point, you can go to the Options Menu and press Skip Puzzle.
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